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KMID : 0390620110190020095
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Journal of Cardiovascular Ultrasound
2011 Volume.19 No. 2 p.95 ~ p.98
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Reversible Symptomatic Myocarditis Induced by All-Trans Retinoic Acid Administration during Induction Treatment of Acute Promyelocytic Leukemia: Rare Cardiac Manifestation as a Retinoic Acid Syndrome
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Choi Seong-Hoon
Kim Hyeong-Su
Jung Chang-Soo
Jung Seong-Woong
Lee Yun-Ja
Rheu Jin-Kyeong
Jo Jung-Rae
Lee Nam-Ho
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Abstract
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Treatment by All-trans retinoic acid (ATRA) followed by anthracycline-AraC chemotherapy has improved the outcome of acute promyelocytic leukemia. ATRA is usually well tolerated, but a few major side effects can be observed. Retinoic acid syndrome (RAS) often occurs during the induction chemotherapy of acute promyelocytic leukemia. A pericardial effusion is a common cardiac manifestation but myocarditis has been rarely documented. Here we reports a very rare case of fully recovered myocarditis as a result of RAS related to ATRA administration during induction treatment of acute promyelocytic leukemia which documented by echocardiographic evidence.
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KEYWORD
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Myocarditis, Retinoic acid syndrome, Acute promyelocytic leukemia
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